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Search Results for " vitamin K "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T36730	Vitamin K1 2,3-epoxide	Vitamin K1 epoxide,Phylloquinone oxide,Vitamin K1 2,3-epoxide	Others
	Vitamin K1 2,3-epoxide (Phylloquinone oxide) is reduced to vitamin k and is involved in the vitamin k cycle.		Others
T7636	Phenprocoumon
	Phenprocoumon is an antagonist of vitamin K(IC50:1 μM).
T5963	Menadione bisulfite sodium	Sodium menadione bisulfite,Menadione sodium bisulfite,Vitamin K3 sodium bisulfite	Others
	Menadione bisulfite sodium (Vitamin K3 sodium bisulfite) is used clinically in China to treat hemorrhagic diseases caused by vitamin K deficiency and globally as a vitamin K supplement.		Others
T0360	Chlorindione	chlophenadione,Indaliton,G-25766
	Chlorindione (chlophenadione) is a vitamin K antagonist, a potent anticoagulant compound.
T17025	Tecarfarin	ATI-5000,ATI-5923	Others
	Tecarfarin (ATI-5923) is an orally active and potent vitamin K epoxide reductase (VKOR) antagonist and cannabinoid-1 receptor inverse agonist with antithrombotic activity that attenuates abdominal pain and increases inte...		Others
T4980	Betrixaban maleate		Factor Xa
	Betrixaban maleate is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa.		Factor Xa
T4341	Betrixaban	PRT054021	Factor Xa
	Betrixaban (PRT054021) is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among all lead compounds due to its low hERG channel ...		Factor Xa
T10867	Coumetarol	Ph 137,Dicumoxane
	Coumetarol is an antagonist of vitamin K.
T75435	Cis-Vitamin K1
	Cis-Vitamin K1 is an endogenous metabolite of Vitamin K [1] .
T17024	Tecarfarin sodium	ATI-5923 sodium	Others
	Tecarfarin sodium is a novel orally active non-competitive vitamin K epoxide reductase antagonist. Tecarfarin sodium has the antithrombotic activity.		Others
T71543	Difethialone
	Difethialone is an anticoagulant rodenticide and a vitamin K antagonist.
T19708	(S)-Warfarin
	(S)-Warfarin is a more effective enantiomer of Warfarin. It is used as a vitamin K antagonist, with anticoagulant.
T62662	Tioclomarol
	Tioclomarol is a coumarin anticoagulant and a vitamin K antagonist.
T36725	6-hydroxy Warfarin
	6-Hydroxywarfarin is a metabolite of (+)-warfarin and a weak vitamin K antagonist.
TP1628	Activated Protein C (390-404), human
	Activated Protein C (390-404), human, a peptide derived from the vitamin K-dependent serine protease, effectively suppresses the anticoagulant activity of APC[1].
T12442	Phenindione D5	Rectadione D5	Others
	Phenindione D5 is deuterium labeled Phenindione, which functions as a Vitamin K antagonist.		Others
T81205	SARS-CoV-2-IN-66		SARS-CoV
	SARS-CoV-2-IN-66 (1), a derivative of vitamin K, functions as an inhibitor of SARS-CoV-2, exhibiting an effective concentration (EC50) of 70.8 μM in VeroE6/TMPRSS2 cells [1].		SARS-CoV
T37950	2-(Isopentylamino)naphthalene-1,4-dione
	2-(Isopentylamino)naphthalene-1,4-dione is a vitamin K analog.1It inhibits spasms induced by pentylenetetrazole and tonic hindlimb extension induced by maximal electroshock (MES) in mice (ED50s = 349.2 and 108.1 mg/kg, r...
T81204	SARS-CoV-2-IN-67		SARS-CoV
	SARS-CoV-2-IN-67 (Compound 16), a derivative of vitamin K, exhibits anti-SARS-CoV-2 properties, with an effective concentration (EC50) of 64.8 μM in VeroE6/TMPRSS2 cells, and inhibits SARS-CoV-2 RdRp activity [1].		SARS-CoV
T22676	Prothrombin (474-477) [Mus musculus]		Others
	Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothro...		Others
T36203	Menaquinone 9	MK-9,Vitamin K2(45),Menaquinone 9
	Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli. MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain. ...
T21693	PPM-18
	PPM-18 (NSC 73233) is a potent anti-inflammatory agent which inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter [1]. PPM-18 is an analo...
T0815L	Warfarin sodium
	An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, an...
T36564	(S)-Acenocoumarol
	Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated...

Compounds

Vitamin K1 2,3-epoxide

T36730

Synonym: Vitamin K1 epoxide,Phylloquinone oxide,Vitamin K1 2,3-epoxide

Menadione bisulfite sodium

T5963

Synonym: Sodium menadione bisulfite,Menadione sodium bisulfite,Vitamin K3 sodium bisulfite

Target: Others

Chlorindione

T0360

Synonym: chlophenadione,Indaliton,G-25766

Target:

Tecarfarin

T17025

Synonym: ATI-5000,ATI-5923

Synonym: Ph 137,Dicumoxane

Synonym: ATI-5923 sodium

Activated Protein C (390-404), human

Synonym: Rectadione D5

2-(Isopentylamino)naphthalene-1,4-dione

Prothrombin (474-477) [Mus musculus]

Synonym: MK-9,Vitamin K2(45),Menaquinone 9

カタログ番号	製品名	別名	ターゲット
T19603	Vitamin K	Kephton,Vitamin K1(20)	Endogenous Metabolite
	Vitamin K (Kephton) has blood coagulation action and is important for coagulation factors, matrix-Gla protein, and osteocalcin.		Endogenous Metabolite
T0449	Menadione	Vitamin K3	Thrombin , Endogenous Metabolite
	Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.		Thrombin , Endogenous Metabolite
T2336	Vitamin K2	Menatetrenone	Endogenous Metabolite
	Vitamin K2 (Menatetrenone) is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity. Menatetrenone may act by modulating the signaling of certain tyrosine kinases, thereby affecting several...		Endogenous Metabolite
T1075	Vitamin K1	Phylloquinone,Phytomenadione,Phytonadione,Phyllohydroquinone	Others , Endogenous Metabolite
	Vitamin K1 (Phylloquinone) a fat-soluble, naturally occurring vitamin with antihemorrhagic and prothrombogenic activity.		Others , Endogenous Metabolite
T2570	Vitamin K4	Kapilin,Menadiol Diacetate,acetomenaphthone	Apoptosis , Endogenous Metabolite
	Vitamin K4 (Menadiol Diacetate) is a vitamin medicine for the treatment of blood coagulation disorders that caused by the lack of VK4.		Apoptosis , Endogenous Metabolite
T7106	Menaquinone-4	Vitamin K2,Menaquinone K4	Others , Endogenous Metabolite
	Menaquinone-4 (Vitamin K2) is a vitamin K compound used as a hemostatic agent, and also as adjunctive therapy for the pain of osteoporosis.		Others , Endogenous Metabolite
T7050	Alpha-Tocopherolquinone	Metarene	Antioxidant
	During hypoxia in rats, levels of α-tocopherylquinon have been found to rise. alpha-Tocopherolquinone (Metarene) is reported to downregulate the respiratory activity of mitochondria. alpha-Tocopherolquinone has also disp...		Antioxidant
T0809	Dicoumarol	Dicumarol	Dehydrogenase , NADPH , PDK
	Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; t...		Dehydrogenase , NADPH , PDK
TQ0197	Acenocoumarol
	Acenocoumarol is a Vitamin K antagonist and used as an anticoagulant.
T14291	Anisindione		Others
	Anisindione is a synthetic anticoagulant and an indanedione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibi...		Others

天然物製品

Vitamin K

T19603

Synonym: Kephton,Vitamin K1(20)

Target: Endogenous Metabolite

Menadione

T0449

Synonym: Vitamin K3

Target: Thrombin, Endogenous Metabolite

Vitamin K2

T2336

Synonym: Menatetrenone

Target: Endogenous Metabolite

Vitamin K1

T1075

Synonym: Phylloquinone,Phytomenadione,Phytonadione,Phyllohydroquinone

Target: Others, Endogenous Metabolite

Vitamin K4

T2570

Synonym: Kapilin,Menadiol Diacetate,acetomenaphthone

Target: Apoptosis, Endogenous Metabolite

Menaquinone-4

T7106

Synonym: Vitamin K2,Menaquinone K4

Target: Others, Endogenous Metabolite

alpha-Tocopherolquinone

Target: Dehydrogenase, NADPH, PDK

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04830	GAS6 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin ...
TMPY-01101	Coagulation factor X/F10 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the...
TMPY-02215	Coagulation factor IX/F9 Protein, Human, Recombinant (His)	Human	HEK293
	Coagulation factor IX, also known as Christmas factor, Plasma thromboplastin component and PTC, is a secreted protein which belongs to the peptidase S1 family. Coagulation factor IX / F9 contains two EGF-like domains, on...
TMPY-01104	Coagulation factor XI/F11 Protein, Human, Recombinant (His)	Human	HEK293
	Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the p...
TMPY-03880	Protein C Protein, Human, Recombinant (His)	Human	HEK293
	PROC (protein C gene) is a 62-kDa vitamin K-dependent plasma zymogen which, after activation to serine protease, plays an important role in the physiologic regulation of blood coagulation. Originally thought to be synthe...
TMPY-04029	Protein C Protein, Mouse, Recombinant (His)	Mouse	HEK293
	PROC (protein C gene) is a 62-kDa vitamin K-dependent plasma zymogen which, after activation to serine protease, plays an important role in the physiologic regulation of blood coagulation. Originally thought to be synthe...
TMPH-02882	NQO2 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma...
TMPK-00517	GAS6 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of ...
TMPY-03257	Calumenin Protein, Human, Recombinant (His)	Human	HEK293
	Calumenin belongs to the CREC family. It contains 6 EF-hand domains. Calumenin is expressed in skeletal muscle (at protein level). Calumenin interacts with GGCX and RYR1 in the presence of calcium ions, but not in the pr...
TMPY-06315	Protein S/PROS1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	PROS1, also known as protein S, is a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. PROS1 has two isoforms: a free,...
TMPY-06708	Protein S/PROS1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	PROS1, also known as protein S, is a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. PROS1 has two isoforms: a free,...
TMPJ-00301	Coagulation Factor X Protein, Human, Recombinant (hFc)	Human	Human Cells
	F10, also known as Coagulation factor X, belongs to the peptidase S1 family that is synthesized as a 488 amino acid (aa) with a signal peptide and a pro region (residues 1‑40). Both the intrinsic and extrinsic pathways a...
TMPY-05355	Coagulation factor IX/F9 Protein, Human, Recombinant (hFc)	Human	HEK293
	Coagulation factor IX, also known as Christmas factor, Plasma thromboplastin component and PTC, is a secreted protein which belongs to the peptidase S1 family. Coagulation factor IX / F9 contains two EGF-like domains, on...
TMPY-06714	Coagulation factor IX/F9 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Coagulation factor IX, also known as Christmas factor, Plasma thromboplastin component and PTC, is a secreted protein which belongs to the peptidase S1 family. Coagulation factor IX / F9 contains two EGF-like domains, on...
TMPJ-01081	Dtk Protein, Human, Recombinant (His)	Human	Human Cells
	Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs an...
TMPJ-00707	Coagulation factor X/F10 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Mouse coagulation factor X / F10 a member of the peptidase S1 family. The mature F10 is composed mostly of two EGF-like domains, one Gla gamma-carboxy-glutamate domain and one peptidase S1 domain. Factor Xa is a vitamin ...
TMPJ-00449	AXL Protein, Human, Recombinant (hFc)	Human	Human Cells
	Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl...
TMPJ-00399	AXL Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl...
TMPY-02014	Coagulation factor VII/F7 Protein, Human, Recombinant (His)	Human	HEK293
	Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is...